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Science
Publications and Presentations
Check out our publications and poster presentations.
November 2016
Targeting Tumor Glutamine Metabolism with CB‐839 Enhances the Efficacy of Immune Checkpoint Inhibitors CX-839-004: A Phase 1/2 Study of the Safety, Pharmacokinetics, and Pharmacodynamics of the Glutaminase Inhibitor CB-839 in Combination with Nivolumab in Patients with Clear Cell Renal Cell Carcinoma and Other Solid TumorsSociety for Immunotherapy of Cancer
July 2016
CB-1158 Inhibits the Immuno-oncology Target Arginase and Causes an Immune Mediated Anti-Tumor ResponseCharles River Symposium-Immunotherapy
June 2016
Phase 1 study of CB-839, a small molecule inhibitor of glutaminase, alone and in combination with everolimus in patients with renal cell cancer Phase 1 study of CB-839, a small molecule inhibitor of glutaminase in combination with paclitaxel in patients with triple negative breast cancerAmerican Society of Clinical Oncology – June 2016
April 2016
Immuno-Oncology Agent CB-1158 is a Potent and Selective Arginase Inhibitor and Causes an Immune-Mediated Anti-Tumor ResponseAmerican Association of Cancer Research – April 2016
April 2016
Glutaminase Inhibition With CB-839 Enhances Anti-Tumor Activity of PD-1 and PD-L1 Antibodies by Overcoming a Metabolic Checkpoint Blocking T Cell ActivationAmerican Association of Cancer Research – April 2016
Our Pipeline
We are focused on solid tumors for
which new treatments are urgently needed.