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Science
Publications and Presentations
Check out our publications and poster presentations.
November 2016
Phase 1 Study of CB-839, a Small Molecule Inhibitor of Glutaminase, In Combination with Everolimus in Patients with Clear Cell and Papillary Renal Cell Carcinoma CB-839, a selective glutaminase inhibitor, has anti-tumor activity in renal cell carcinoma and synergizes with everolimus and receptor tyrosine kinase inhibitorsNCI AACR EORTC – 2016
November 2016
November 2016
Arginase Inhibitor CB-1158 Alleviates Immunosuppression And Enhances Anti-Tumor Responses As A Single Agent And In Combination With Other Immunotherapies CX-1158-101: A First-in-Human Phase 1 Study of a Small Molecule Inhibitor of Arginase (CB-1158) as Monotherapy and in Combination with an anti-PD-1 Checkpoint Inhibitor in Patients with Solid TumorsSociety for Immunotherapy of Cancer
November 2016
Targeting Tumor Glutamine Metabolism with CB‐839 Enhances the Efficacy of Immune Checkpoint Inhibitors CX-839-004: A Phase 1/2 Study of the Safety, Pharmacokinetics, and Pharmacodynamics of the Glutaminase Inhibitor CB-839 in Combination with Nivolumab in Patients with Clear Cell Renal Cell Carcinoma and Other Solid TumorsSociety for Immunotherapy of Cancer
July 2016
CB-1158 Inhibits the Immuno-oncology Target Arginase and Causes an Immune Mediated Anti-Tumor ResponseCharles River Symposium-Immunotherapy
Our Pipeline
We are focused on solid tumors for
which new treatments are urgently needed.